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Based in Davao City, Mapua Malayan College Mindanao began operations as a spin-off from Mapua University in 2018. These first students studied mechanical, civil, chemical and industrial engineering, information technology, computer science and entrepreneurship.

Students can study at colleges of business, arts and science, computer and information science, engineering and architecture and health sciences.

Students are taught using a method known as "MMCM Flux", standing for "Flexible Learning, Ubiquitous Experience". This is a hybrid design offering "in-person, synchronous and asynchronous classes". Evening classes were launched in 2023.

Other facilities include a Game Development Laboratory.