The MRC has awarded ?10.6 million to projects to develop better models of human disease, including diabetes, stroke, heart disease and age-related macular degeneration. Twenty research groups will benefit and several of the projects will involve collaborations with industry.

Award winner: G. Bates

Institution: King's College London

Value: ?730,518

Identification and cross-validation of early stage phenotypes in mouse models of Huntington's disease

Award winner: N. Thapar

Institution: University College London

Value: ?607,936

Using key models for developing stem-cell-based therapies for aganglionic gut disorders

Award winner: P. Cowen

Institution: University of Oxford

Value: ?382,100

Impaired neural responses to the sight and taste of chocolate: A model of anhedonia in depression

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Award winner: M. Little

Institution: University of Birmingham?

Value: ?378,712?

Towards robust animal models of ANCA-associated vasculitis

Award winner: D. T. Shima

Institution: Institute of Ophthalmology

Value: ?348,032

Qualifying mouse models of spontaneous, progressive age-related macular degeneration

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Award winner: W. P. Duprex

Institution: Queen's University Belfast

Value: ?897,700

Illuminating childhood respiratory infections: from viral diseases to vaccine delivery

Award winner: R. R. Ali

Institution: Institute of Ophthalmology

Value: ?435,316

Pathology and treatment of mouse models of dominant retinal disease

Award winner: O. Albagha

Institution: University of Edinburgh

Value: ?371,532

Characterisation and therapeutic intervention of two novel mouse models of Paget's disease of bone

Award winner: A.M. Gray

Institution: University of Oxford

Value: ?489,472

An outcomes model for type 2 diabetes

Award winner: V. Sboros

Institution: University of Edinburgh

Value: ?710,544

Development of contrast enhanced ultrasonography using the sheep ovarian model of microvascular regulation

Award winner: D. Abraham

Institution: University College London

Value: ?497,356

Genetic models for connective tissue disease, scarring and fibrosis

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Award winner: C. Haslett

Institution: University of Edinburgh

Value: ?634,940

Multimodal smart imaging of critical inflammatory processes in murine models of pulmonary fibrosis

Award winner: M. Bailly

Institution: Institute of Ophthalmology

Value: ?497,792

Combined in vitro and ex vivo model to design novel combinatorial strategies for the modulation of scarring

Award winner: J.M. Collinson

Institution: University of Aberdeen

Value: ?436,992

The pma mouse and the developmental basis of congenital talipes equinovarus (clubfoot)

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Award winner: S. M. Allan

Institution: University of Manchester

Value: ?639,784

Subarachnoid haemorrhage as a valid model for stroke

Award winner: K. Smith

Institution: Institute of Neurology

Value: ?761,372

To develop therapies and a strategy for their translation to treat early lesions in multiple sclerosis

Award winner: S.C. Stanford

Institution: University College London

Value: ?622,644

NK1R knockout mouse model and human genetics of attention deficit hyperactivity disorder

Award winner: K. P. Moore

Institution: University College London

Value: ?415,488

Characterising the D-galactosamine rat model of hepatorenal syndrome

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Award winner: N. Smith

Institution: University of Oxford

Value: ?376,724

Dissecting heart failure mechanisms by integrating in vivo and in vitro data within customised silico models

Award winner: K. Wood

Institution: University of Oxford

Value: ?395,784

Humanised mouse models.